ABSTRACT
Schwannoma, also referred to as neurilemmoma, is a benign tumor of peripheral nerve arising from Schwann cells that form the neural sheath. Schwannoma of ophthalmic interest is rare although it has been reported in relation with the orbit, and less frequently with the uveal tract and conjunctiva. Isolated eyelid schwannoma is extremely uncommon. Up until now, only eight cases have been reported in literature. Herein, we report two cases of eyelid schwannoma.
Subject(s)
Antigens, Neoplasm/metabolism , Eyelid Neoplasms/metabolism , Eyelid Neoplasms/pathology , Eyelid Neoplasms/surgery , Female , Humans , Immunochemistry , Male , Melanoma-Specific Antigens , Middle Aged , Neoplasm Proteins/metabolism , Neurilemmoma/metabolism , Neurilemmoma/pathology , Neurilemmoma/surgery , Rare Diseases , S100 Proteins/metabolism , Young AdultABSTRACT
Schwannomas or neurilemmomas are benign, slow growing, usually solitary and encapsulated tumor, originating from Schwann cells of the nerve sheath. Intraoral schwannoma accounts for 1% of head and neck region and are commonly seen at the base region of tongue. Most of the few such reports in the literature, have described schwannomas that occurred in the tongue. In this article, we report a rare case of lingual schwannoma involving the anterior of tongue, in a young individual, in whom the lesion was completely excised via an intra oral approach.
Subject(s)
Child , Humans , Immunohistochemistry , Male , Neurilemmoma/metabolism , Oral Surgical Procedures , Tongue Neoplasms/metabolismABSTRACT
The present study was addressed to find out the expression of Bcl2 proto-oncogene in tumor tissues derived from 25 patients with primary central nervous system tumors. Brain parenchyma in 8 cases, with deeply located tumor, was also examined for Bcl2 expression which served as control. Both benign and malignant tumors (confirmed by histopathological examination) expressed Bcl2 gene product. Tumors exhibited 2-6 fold increase in Bcl2 expression as compared to the normal parenchyma adjacent to some of these tumors studied. However, no correlation was found between the histopathological types of tumor, glial fibrillary acidic protein positivity and degree of Bcl2 expression. Based on this study, we propose that the overexpression of Bcl2 gene product found in primary CNS tumors may be an important molecular event which is known to make the various types of tumor resistant to chemotherapy or radiotherapy.
Subject(s)
Adenoma/metabolism , Adult , Astrocytoma/metabolism , Brain Neoplasms/metabolism , Child , Ependymoma/metabolism , Female , Glioblastoma/metabolism , Humans , Male , Meningeal Neoplasms/metabolism , Meningioma/metabolism , Middle Aged , Neurilemmoma/metabolism , Proto-Oncogene Proteins c-bcl-2/biosynthesisABSTRACT
El origen de los tumores mesenquimáticos del tracto gastrointestinal tradicionalmente considerados musculares ha sido recientemente debatido postulándose que algunos de ellos serían en realidad derivados de células del sistema nervioso periférico. En el presente trabajo hemos estudiado una serie de tumores mesenquimáticos digestivos empleando un antisuero para S-100 y dos antisueros para proteínas de filamentos intermedios: la proteína gliofibrilar ácida (PGFA), y la desmina. La técnica utilizada fue la de peroxidasa-antiperoxidasa empleando antisueros policlonales obtenidos de DAKO (Dinamarca). Se estudiaron 24 tumores mesenquimáticos del tracto digestivo (Tabla 1). Las localizaciones fueron: 1 de esófago, 16 de estómago, 6 de intestino delgado y 1 de colon. Los mismos fueron diagnosticados como: leiomioma (18 casos), leiomioblastoma (3 casos) y leiomiosarcomas (3 casos). Como grupo control se estudiaron 5 leiomiomas uterinos. Estos resultaron uniformemente positivos para desmina y negativos para S-100 y PGFA. Diez casos fueron positivos con el antisuero para desmina; correspondiendo éstos a 9 leiomiomas y 1 leiomioblastoma (Tabla 2). Seis (25%) de los tumores expresaron marcadores neurales: 5 fueron positivos con S-100, 4 con PGFA y correspondieron a 3 leiomiomas, 1 leiomioblastoma y 2 leiomiosarcomas. En ningún tumor se observó tinción simultánea para desmina y algunos de los marcadores neurales. Ocho casos (33%) fueron negativos con todos los antisueros empleados siendo: 6 leiomiomas; 1 leiomioblastoma y 1 leiomiosarcomas. Nuestros resultados sugieren la existencia de por lo menos dos grupos de tumores de acuerdo a sus características inmunohistoquímicas: aquellos de origen miogénico y los derivados de células del sistema periférico. Los tumores negativos para ambos grupos de marcadores podrán probablemente ser clasificados mediante otras técnicas inmunohistoquímicas o ultraestructurales...